| 产品详情 |
| Edit |   |
|---|
| Product Name | PIM3 Kinase Inhibitor VII, M-110 |
|---|
| Description | Purity ~97% (HPLC). A cell-permeable hydroxyphenyl-propylidene-benzohydrazide compound that acts as a potent, ATP-competitive (Ki = 0.3uM), and highly isoform-selective PIM inhibitor (IC50 = 2.5, 2.5, and 0.047uM against PIM1, PIM2, and PIM3, respectively; [ATP] = 10uM), while affecting CK2alpha2 only at much higher concentrations (IC50 = 5uM, [ATP] = 10uM) and exhibiting little or no activity against a panel of 258 other kinases (<40% inhibition at 5uM). Shown to inhibit PIM3-dependent STAT3 Tyr705 phosphorylation in DU-145 prostate cancer and MiaPaCa2 pancreatic cancer cells (by 73% and 83%, respectively; 10uM for 18h), while displaying little effect toward STAT3 Tyr694 phosphoylation in 22RV1 cultures. Formula: C22H28ClN5O3 Solubility: DMSO Molar Mass: 445.9 |
|---|
| Size | 10mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | PIM3 Kinase Inhibitor VII, M-110 (N'-(1-(4-Chloro-2-hydroxyphenyl)propylidene)-2-((3-morpholinopropyl)amino)isonicotinohydrazide) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217664 |
|---|
| Price | |
|---|
| Order / More Info | PIM3 Kinase Inhibitor VII, M-110 from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|