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| Product Name | NDP, 25-133aa, Human, His tag, E Coli (Denatured) |
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| Description | MW: 14.8 kDa (132aa). Purity >80% by SDS-PAGE. Norrin precursor, also known as NDP, is a secreted regulatory protein. It activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. This protein plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. It may be involved in a pathway that regulates neural cell differentiation and proliferation. Reco |
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| Size | 0.05 mg, 0.25 mg |
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| Concentration | 0.5 mg/ml (determined by Bradford assay) |
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| Applications | SDS-PAGE |
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| Other Names | [Norrin; EVR2; FEVR; ND] |
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| Gene, Accession, CAS # | NDP, Gene ID: 4693, Accession: NP_000257 |
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| Catalog # | MBS204869 |
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| Order / More Info | NDP, 25-133aa, Human, His tag, E Coli (Denatured) from MYBIOSOURCE INC. |
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| Product Specific References | Luhmann u F., et al. (2005) Invest Pothalmol Vis Sci. 46:3372-3382.; Luhmann u F., et al. (2005) Genesis. 42:253-262 |
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