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| Product Name | RAGE, Recombinant, Canine |
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| Description | Purity ≥ 90%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain.Endotoxin: ≤ 1EU/1ug. Advanced glycation endproducts (AGEs) are adducts formed by the nonenzymatic glycation of macromolecules. AGE formation is accelerated in oxidative and hyperglycemic conditions, diabetes, renal failure, atherosclerosis, Alzheimer's disease, arthritis, and in normal aging (1-5). Receptor for advanced glycation endproducts (RAGE) is a 35kD type I transmembrane protein belonging the immunoglobulin superfamily. Besides AGEs, RAGE binds b-amyloid peptide, S100/calgranulin family proteins, HMGB1/amphoterin, and leukocyte integrins (6-9). Mature canine RAGE consists of a 383 amino acid (aa) extracellular domain (ECD) with one Ig-like V-type domain and two Ig-like C-type domains, a 23 aa transmembrane segment, and a 43 aa cytoplasmic domain (10). Within the ECD, canine RAGE shares 73%-77% aa sequence identity with human, mouse, and rat RAGE. In human, soluble forms of RAGE ar |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | RAGE, Recombinant, Canine (Receptor for Advanced Glycosylation End Products, Advanced Glycosylation End Product-specific Receptor, AGER) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | R1031-15C |
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| Order / More Info | RAGE, Recombinant, Canine from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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