| 产品详情 |
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| Product Name | PF-477736 |
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| Description | Purity >98%. Checkpoint kinase 1 (Chk1) regulates S and G2 -M phase cell cycle checkpoints in response to DNA damage. PF-477736 is an ATP-competitive inhibitor of Chk1 with a Ki value of 0.49 nM that demonstrates 100-fold selectivity over Chk2. When used in combination with various chemotherapeutics, PF-477736 abrogates DNA damage-induced cell cycle arrest, potentiating the antiproliferative effects of these compounds in tumor cell lines and xenografts. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (aR)-amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]-cyclohexaneacetamide |
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| Gene, Accession, CAS # | CAS: 952021-60-2 |
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| Catalog # | LS-H9348 |
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| Order / More Info | PF-477736 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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