| 产品详情 |
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| Product Name | PF-4989216 |
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| Description | Purity >98%. PF-4989216 is an orally bioavailable broad-spectrum PI3K inhibitor (IC50 s = 2, 142, 65, 1, and 110 nM for p110Alpha, p110Beta, p110Gamma, p110Delta, and VPS34, respectively). It inhibits the cell viability of small-cell lung cancer (SCLC) cells with a mutation in PIK3CA, blocking PI3K downstream signaling and inducing apoptosis. PF-4989216 prevents tumor growth of SCLC cells harboring PIK3CA mutation in mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-(4-cyano-2-fluorophenyl)-2-(4-morpholinyl)-5-(1H-1,2,4-triazol-5-yl)-3-thiophenecarbonitrile |
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| Gene, Accession, CAS # | CAS: 1276553-09-3 |
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| Catalog # | LS-H9350 |
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| Order / More Info | PF-4989216 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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