| 产品详情 |
| Edit |   |
|---|
| Product Name | PF-543 |
|---|
| Description | Purity >98%. PF-543 is a potent inhibitor of sphingosine kinase 1 (SK1; IC50 = 2-3.6 nM) that less effectively inhibits SK2 (IC50 = 356 nM). It does not significantly block the activity of other protein and lipid kinases, or bind sphingosine-1-phosphate receptors, when tested at a concentration of 10 µM. PF-543 prevents the phosphorylation of sphingosine in cancer cells and in whole blood (EC50 s = 8.4 and 27 nM, respectively). Through its effects on SK1, PF-543 prevents sickling, hemolysis, and inflammation in sickling cell disease transgenic mice. Unlike inhibitors that are selective for SK2, PF-543 does not impair DNA synthesis in human pulmonary arterial smooth muscle cells. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 1-[[4-[[3-methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2R-pyrrolidinemethanol |
|---|
| Gene, Accession, CAS # | CAS: 1415562-82-1 |
|---|
| Catalog # | LS-H9352 |
|---|
| Price | |
|---|
| Order / More Info | PF-543 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|