| 产品详情 |
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| Product Name | PF-9184 |
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| Description | Purity >98%. Microsomal prostaglandin E synthase-1 (mPGES-1) converts the COX product prostaglandin H2 (PGH2 ) into the biologically active PGE2 . Like COX-2, the expression of mPGES-1 is induced in response to pro-inflammatory mediators, including LPS, IL-1Beta, and TNF-Alpha. PF-9184 is a potent inhibitor of mPGES-1 (IC50 = 16.5 nM for recombinant human enzyme). It displays at least 6,500-fold selectivity for mPGES-1 over COX-1 and COX-2. PF-9184 blocks the synthesis of PGE2 in LPS-treated human whole blood and in IL-1Beta-stimulated fibroblasts (IC50 s = 0.4-5 µM). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(3',4'-dichloro[1,1'-biphenyl]-4-yl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide |
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| Gene, Accession, CAS # | CAS: 1221971-47-6 |
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| Catalog # | LS-H9356 |
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| Price | |
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| Order / More Info | PF-9184 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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