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| Product Name | UBE2K (UBC1) Recombinant protein |
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| Description | MW: ~25 kDa. Recombinant full length human UBE2K (UBC1) was expressed in E. coli cells using an N-terminal His tag.Scientific Background: UBE2K also known as UBC1 or ubiquitin-conjugating enzyme E2K belongs to the ubiquitin-conjugating enzyme family which interacts with RING finger proteins. UBE2K can ubiquitinate huntingtin, the gene product for Huntington's disease. Huntingtin is ubiquitinated in peripheral cells, suggesting a role for UBE2K in the degradation of huntingtin (1). |
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| Size | 0.02 mg, 0.05 mg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Other Names | [E2-25K; HIP2; HYPG; LIG; UBC1; UBE2K(UBC1) Protein] |
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| Gene, Accession, CAS # | UBE2K (UBC1), Gene ID: 3093, Accession: NP_005330.1 |
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| Catalog # | MBS515093 |
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| Order / More Info | UBE2K (UBC1) Recombinant protein from MYBIOSOURCE INC. |
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| Product Specific References | 1. Kalchman, M. A. et.al: Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme. J. Biol. Chem. 271: 19385-19394, 1996. 2. De Pril, R. et al: Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases. Mol Cell Neurosci. 2007 Jan;34(1):10-9. |
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