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| Product Name | Nosiheptide Precursor, Recombinant, Streptomyces Actuosus, aa1-50, GST-Tag (NosM) |
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| Description | Purity ~90% (SDS-PAGE). Inhibits bacterial protein biosynthesis by binding to ribosomes. Specifically, binds to the complex of 23S rRNA and ribosomal protein L11 (RPLK) in the 50S ribosomal subunit. While allowing a weak binding of elongation factor G (EF-G) to the ribosome and subsequent GTP-hydrolysis, probably impairs conformational changes in both the ribosome and EF-G which are necessary for translocation. In vitro, inhibits Gram-positive bacteria S.aureus strain 209P (MIC=0.0009 µg/ml), S.aureus strain 133 (MIC=0.0019 µg/ml), S.aureus strain B3 (MIC=0.003 µg/ml), S.aureus strain Hb (MIC=0.003 µg/ml), M.citreus strain ATCC 8411 (MIC=0.0038 µg/ml), M.lysodeikticus strain ATCC 4698 (MIC=0.003 µg/ml), S.lutea strain ATCC 9341 (MIC=0.0011 µg/ml), S.faecalis strain ATCC 9790 (MIC=0.0007 µg/ml), S.viridans (MIC=0.0065 µg/ml), S.pyogenes hemolyticus strain Dig7 (MIC=0.00028 µg/ml), D.pneumoniae strain Til (MIC=0.00015 µg/ml), N.catrrhalis (MIC=0.0017 µg/ml), L.casei strain ATCC 6633 (MIC=0.003 µg/ml), B.cereus |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Antibiotic 9671-RP1 Publication Multhiomycin |
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| Gene, Accession, CAS # | SwissProt: C6FX52 |
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| Catalog # | 374443 |
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| Order / More Info | Nosiheptide Precursor, Recombinant, Streptomyces Actuosus, aa1-50, GST-Tag (NosM) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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