| 产品详情 |
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| Product Name | DUB Inhibitor VI, P22077 |
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| Description | Purity ~98% (HPLC). A cell-permeable thiophenylethanone that is shown to inhibit USP7 and USP47 deubiquitinase activity (IC50=8.01 & 8.74uM, respectively), while exhibiting much reduced affinity toward ATXN3, BAP1, and USP1, and displaying no inhibitory activity toward other known PR-619 targets (IC50 >50uM). Both P22077 and PR-619 are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150uM; 0.5 to 20h), however PR619 treatment results in upregulation of both K48- and K63-linked, while P22077 exposure results in mainly enrichment of K48-linked polyUb chains. Formula: C12H7F2NO3S2 Molecular Weight: 315.3 Solubility: DMSO (50mg/ml) |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | DUB Inhibitor VI, P22077 (1-(5-(2,4-Difluorophenylthio)-4-nitrothiophen-2-yl)ethanone, USP7 Inhibitor II, USP47 Inhibitor II) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217330 |
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| Order / More Info | DUB Inhibitor VI, P22077 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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