| 产品详情 |
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| Product Name | DUB Inhibitor V, PR-619 |
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| Description | Purity ~99% (HPLC). A cell-permeable pyridinamine class broad-spectrum DUB inhibitor whose known targets include ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. Both PR-619 and P22077 are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150uM; 0.5 to 20h), however P22077 exposure results in mainly enrichment of K48-linked, while PR619 treatment results in upregulation of both K48- and K63-linked polyUb chains. Solubility: DMSO (50mg/ml) Proton NMR: Conforms LC-MS: Conforms Carbon: 35-38% Hydrogen: 1.5-3.5% Nitrogen: 29-32% Sulfur: 27-30% Water by CHN (mol): ≤2mol |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PR619; UCH-L1 Inhibitor IV; UCH-L3 Inhibitor II; UCH-L5/UCH37 Inhibitor III; USP5 Inhibitor II; USP7 Inhibitor I; USP9X Inhibitor II; USP14 Inhibitor IV; USP14 Inhibitor IV; USP47 Inhibitor I; 2,6-Diaminopyridine-3,5-bis(thiocyanate); 3,5-Dithiocyanatopyridine-2,6-diamine |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217329 |
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| Order / More Info | DUB Inhibitor V, PR-619 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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