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| Product Name | TGF-b1, Recombinant, Human (Transforming Growth Factor Beta 1, TGFB1) |
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| Description | Purity ~95% (SDS-PAGE). TGF-b1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-b superfamily that share a characteristic cystine knot structure (1-7). TGF-b1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition (1-4). Each TGF-b isoform has some non-redundant functions; for TGF-b1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation, and die of overwhelming inflammation (2). Human TGF-b1 cDNA encodes a 390aa precursor that contains a 29aa signal peptide and a 361aa proprotein (8). A furin-like convertase processes the proprotein to generate an N-terminal 249aa latency-associated peptide (LAP) and a C-terminal 112aa mature TGF-b1 (8, 9). Disulfide-linked homodimers of LAP and TGF-b1 remain non-covalently associated after secretion, forming the small latent TGF |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P01137 |
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| Catalog # | 167702 |
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| Order / More Info | TGF-b1, Recombinant, Human (Transforming Growth Factor Beta 1, TGFB1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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