| 产品详情 |
| Edit |   |
|---|
| Product Name | CaCC Blocker IV, Benzbromarone |
|---|
| Description | Purity ~97% (HPLC). A cell-permeable uricosuric agent that, in addition to its known efficacy in gout treatment, acts as a reversible CaCC blocker and is reported to be more potent than NFA and NPPB in suppressing 500nM Ionomycin- induced I- influx in TMEM16A-expressing HEK293 cells (IC50 = 9.97, 140, and 150uM, respectively) as well as in blocking voltage-gated Cl- current in TMEM16B-expressing HEK293 cells, while exhibiting much reduced potency against ENaC (alpha, beta, and gamma) or CFTR. Shown to significantly reduce mucin secretion from NHBE (normal human bronchial epithelial) and suppress human ASM (airway smooth muscle) contraction upon muscarinic receptor stimulation. Solubility: DMSO Primary Target: TMEM16A-CaCC Molar Mass: 424.1 |
|---|
| Size | 100mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | CaCC Blocker IV, Benzbromarone (CaCC Blocker IV, Calcium-Activated Chloride Channel Blocker IV, TMEM16 Blocker IV, (3,5-dibromo-4-hydroxyphenyl)(2-ethylbenzofuran-3-yl)methanone, ANO Blocker IV, Anoctamin Blocker IV, BBR) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217236 |
|---|
| Price | |
|---|
| Order / More Info | CaCC Blocker IV, Benzbromarone from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|