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| Product Name | Hepatitis B Virus, x, Recombinant (HBx, rHBx) |
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| Description | Purity ~95% (SDS-PAGE). Hepatitis B virus X protein (HBx) is a ~17kD transcriptional coactivator that plays a significant role in the regulation of genes involved in inflammation and cell survival. It regulates many transcription factors including nuclear factor kappa B (NF-kappaB) and plays a key role in hepatocarcinogenesis. rHBx facilitates the binding of cAMP response element binding protein (CREB) to its responsive element. rHBx stabilizes the cellular coactivator ASC-2 through direct protein-protein interaction, affecting the regulation of genes actively transcribed in liver cancer cells. HBx transactivates both JNK and MAPK signal transduction pathways in association with the mobilization of cytosolic Ca2+. The communication between HBx and general transcription factor TFIIB is also one of the mechanisms which account for its transcriptional transactivation. HBx decreased the expression of PTEN a known tumor suppressor and a negative regulator of phosphatidylinositol 3'-kinase/A |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 208973 |
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| Order / More Info | Hepatitis B Virus, x, Recombinant (HBx, rHBx) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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