| 产品详情 |
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| Product Name | CB-5083 |
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| Description | Purity >95%. CB-5083 is an orally bioavailable inhibitor of p97 (IC50 = 11 nM), a transitional endoplasmic reticulum ATPase also known as valosin-containing protein (VCP). It disrupts cellular protein homeostasis and demonstrates anti-tumor activity in hematological and solid tumor models. CB-5083 causes accumulation of poly-ubiquitinated proteins, retention of endoplasmic reticulum-associated degradation (ERAD) substrates, and activation of the apoptotic arm of the unfolded protein response. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[7,8-dihydro-4-[(phenylmethyl)amino]-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide |
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| Gene, Accession, CAS # | CAS: 1542705-92-9 |
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| Catalog # | LS-H7015 |
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| Price | |
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| Order / More Info | CB-5083 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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