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| Product Name | 5'-Ethynyl-2'-deoxycytidine |
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| Description | Purity >98%. 5'-Ethynyl-2'-deoxycytidine (EdC) is a nucleoside analog that inhibits replication of the herpes simplex virus-1 (HSV-1) KOS strain (ID50 = 0.2 µg/mL). It also reduces virus-induced cytopathogenicity of HSV-1, HSV-2, and vaccinia virus strains in PRK cells (MICs = 0.2-0.4, 1-2, and 5 µg/ml, respectively). EdC is an inhibitor of thymidylate synthetase, selectively reducing DNA incorporation of [1',2'-3 H]deoxyuridine over [CH3 -3 H]deoxythymidine in PRK cells (ID50 s = 3 and 120 µg/ml, respectively). It inhibits thymidine synthetase in and reduces proliferation of L1210 cells, an effect which is reversed by addition of deoxythymidine (ID50 s = 4.4 and 1,000 µg/ml, respectively). EdC has been used to monitor DNA synthesis and cellular replication via click chemistry conjugation of the ethynyl group to an azido group of various fluorochromes. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2'-deoxy-5-ethynyl-cytidine, 2'-deoxy-5-Ethynylcytidine, EdC |
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| Gene, Accession, CAS # | CAS: 69075-47-4 |
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| Catalog # | LS-H6209 |
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| Order / More Info | 5'-Ethynyl-2'-deoxycytidine from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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