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| Product Name | Interleukin-17A, Mouse, BioAssay™ ELISA Kit (IL-17A) |
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| Description | Mouse Interleukin-17A (mIL-17A), also know as CTLA-8, is a secreted, homodimeric glycoprotein linked by disulfide link with a molecular mass of about 35kD. The cytokine is the proto-type of a newly discovered pro-inflammatory cytokine family which consists of IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (IL-25) and IL-17F. IL-17A is mainly produced by a group of CD4 T helper cells termed Th17 cells. In addition to Th17 cells, CD8 T helper cells, natural killer cells and granulocytes, can also secret the cytokine after proper stimulation. IL17A exhibits structural homology and cross-species bioactivity between human and mouse cells. IL-17A acts through its receptor IL-17R. It was found to stimulate the expression of pro-inflammatory cytokines including IL-6, MCP-1, G-CSF,GM-CSF,IL-1alpha and TNF-alpha. Most of those cytokines plays a role in the proliferation, maturation and chemotaxis of neutrophils. Elevated levels of IL-17A have been found to implicate with autoimmune diseases, airway infl |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 216008 |
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| Order / More Info | Interleukin-17A, Mouse, BioAssay™ ELISA Kit (IL-17A) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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