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| Product Name | Interleukin-17A , Recombinant, Mouse, aa26-158 (IL-17A, CTLA-8) |
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| Description | Purity ~95% (SDS-PAGE). Interleukin-17A (IL-17A), also known as CTLA-8, is a 15-20kD glycosylated cytokine that plays an important role in anti-microbial and chronic inflammation. The six IL-17 cytokines (IL-17A-F) are encoded by separate genes but adopt a conserved cystine knot fold (1, 2). Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively (3, 4). IL-17A is secreted by Th17 cells, gamma/delta T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells (2). It forms disulfidelinked homodimers as well as disulfide-linked heterodimers with IL-17F (5, 6). IL-17A exerts its effects through the transmembrane IL-17 RA in complex with IL-17 RC or IL-17 RD (7, 8). Both IL-17 RA and IL-17 RC are required for responsiveness to heterodimeric IL-17A/F (7). IL-17A promotes protective mucosal and epidermal inflammation in response to microbial infection (9-12). It induces chemokine production, neutrophil influx, and th |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q62386 |
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| Catalog # | 145711 |
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| Order / More Info | Interleukin-17A , Recombinant, Mouse, aa26-158 (IL-17A, CTLA-8) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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