| 产品详情 |
| Edit |   |
|---|
| Product Name | Interleukin-36 beta, active (Il36b), Recombinant, Mouse |
|---|
| Description | Purity ≥95% as determined by SDS-PAGE and HPLC. Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 10e3 as well as a number of matrix metalloproteases (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, |
|---|
| Size | 2ug, 10ug, 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Interleukin-1 family member 8, |
|---|
| Gene, Accession, CAS # | IL36B_MOUSE, SwissProt: Q9D6Z6 |
|---|
| Catalog # | 348134 |
|---|
| Price | |
|---|
| Order / More Info | Interleukin-36 beta, active (Il36b), Recombinant, Mouse from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|