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| Product Name | Interleukin-1 beta, Human, BioAssay™ ELISA Kit (IL-1 beta, Catabolin, IL-1B, IL1F2, IL1-beta) |
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| Description | Sandwich ELISA quantitative detection kit for Human IL-1 beta in cell culture supernates, serum and plasma (heparin, EDTA, citrate). Interleukin-1b ( IL-1b) is a potent stimulator of bone resorption whose gene is mapped to 2q14, and has been implicated in the pathogenesis of high bone turnover and osteoporosis. IL-1b, a prominent microglia-derived cytokine, caused oligodendrocyte death in coculture with astrocytes and microglia, but not in pure culture of oligodendrocytes alone. It also can cause nuclear export of a specific NCOR corepressor complex, resulting in derepression of a specific subset of nuclear factor-kappa-B (NFKB)-regulated genes2. Furthermore, Microenvironmental IL-1b and, to a lesser extent, IL-1a are required for in vivo angiogenesis and invasiveness of different tumor cells. Additional, the cooperation of IL-1b and PDGFB induces contractile-to-synthetic phenotype modulation of human aortic smooth muscle cells in culture. Moreover, the association with disease may be |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 3553, SwissProt: P01584 |
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| Catalog # | 143885 |
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| Order / More Info | Interleukin-1 beta, Human, BioAssay™ ELISA Kit (IL-1 beta, Catabolin, IL-1B, IL1F2, IL1-beta) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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