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| Product Name | COX 2, His-Tag, Recombinant, Human |
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| Description | Purity ≥ 70%. The prostanoid family includes PGD2, PGE2, PGF2alpha, PGI2, thromboxane A2 and prostaglandins. The prostaglandins (PGs) are implicated in various physiological and pathophysiological events, including male fertility, menstruation, ovulation, pregnancy, implantation and inflamatory and neoplastic diseases. The biosynthesis of PGs and some other prostanoids, is catalyzed in a rate limiting step by PG-H synthase (also known as cyclooxygenase (COX), PG-endoperoxidase synthase (PTGS)) which converts arachidonic acid to prostaglandin/prostanoid precursor PGH2. Two cyclooxygenase isozymes, COX1 (human, 576aa, 69-72kD; chromosome 9) and COX2 (human, 604aa, 74kD; chromosome 1) have been identified. COX1, a constitutively expressed isoform, produces physiologically relevant prostanoids such as those in stomach and platelets. COX2 isoform is inducible and rapidly upregulated at inflamation sites and forms proinflamatory prostanoids. The overexpression of COX-2 also leads to tumeroge |
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| Size | 250U, 1000U, 2500U |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | COX 2, His-Tag, Recombinant, Human (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C7904-84A |
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| Order / More Info | COX 2, His-Tag, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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