| 产品详情 |
| Edit |   |
|---|
| Product Name | S6K1 Inhibitor II, DG2 |
|---|
| Description | Purity ~97% (HPLC). A cell-permeable pyrazolopyrimidine compound that acts as a potent, ATP-competitive and reversible inhibitor of S6K1 (p70 ribosomal protein S6 kinase 1; IC50=9.1nM) with ~2,400 reduced activity towards Akt (IC50=22uM). Shown to completely block rpS6-Ser240/244 phosphorylation in L6 cells at 2.5uM without inducing pAkt-Thr308 and Ser473, and display substantial selectivity in a 219-kinase panel (1uM of DG2 in the presence of 10uM of ATP; IC50 ≥50%; Clk1, Clk2, Dyrk1A, Dyrk3, Flt3, Flt3-D835Y, Flt4, GSK-3a/b, R, MAP4K4, Mink1, PKA, PRKG1, PRKG2, Ret-V804L, Ret-Y791F, RSK1, RSK3, RSK2, MSK2, MSK1 and p70S6K). Formula: C16H17BrN6O Molecular Weight: 389.3 Solubility: DMSO (100mg/ml, clear, pale yellow solution) |
|---|
| Size | 10mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | S6K1 Inhibitor II, DG2 (3-Bromo-4-(4-(2-methoxyphenyl)piperazin-1-yl)-1H-pyrazolo[3,4-d]-pyrimidine) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217773 |
|---|
| Price | |
|---|
| Order / More Info | S6K1 Inhibitor II, DG2 from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|