| 产品详情 |
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| Product Name | S6K1 Inhibitor, PF-4708671 |
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| Description | Purity ~98% (HPLC). A cell-permeable piperazinyl-pyrimidine compound that acts as an inhibitor against S6K1 (Ki=20nM; IC50=160nM) and MSK1 (IC50=950nM) kinase activity, exhibiting little or much reduced potency against 85 other protein and lipid kinases ( IC50=4.7, 9.2, 65uM, respectively, against RSK1, RSK2, and S6K2; <27% inhibition of the rest at 1uM). Shown to selectively inhibit IGF1- and PMA-stimulated S6K1 substrates phosphorylation in HEK-293 cells in a dose-dependent manner (up to 10uM) in vitro and alleviate heart remodeling and functional damage in a MI (myocardial infarction) model in mice in vivo (75/mg/kg/daily i.p.). Formula: C19H21F3N6 Molecular Weight: 390.4 Solubility: DMSO (50mg/ml, pale yellow solution) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | S6K1 Inhibitor, PF-4708671 ((2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole, p70 Ribosomal S6 Kinase 1 Inhibitor) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217774 |
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| Order / More Info | S6K1 Inhibitor, PF-4708671 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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