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| Product Name | Pro-neuregulin-1, membrane-bound isoform, active (NRG1), Recombinant, Human |
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| Description | Purity ≥97% as determined by SDS-PAGE and HPLC. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. (ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:7902537). Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Pro-NRG1, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin |
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| Gene, Accession, CAS # | NRG1_HUMAN, SwissProt: Q02297 |
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| Catalog # | 348207 |
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| Order / More Info | Pro-neuregulin-1, membrane-bound isoform, active (NRG1), Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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