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| Product Name | Apolipoprotein E, Human (Apo E) |
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| Description | Purity ≥98% (SDS-PAGE). The apolipoproteins are family of amphipathic lipoproteins that plays a crucial role in lipid metabolism. In particular, apolipoprotein E (apo E) is a major component of high density lipoproteins (HDL) chylomicrons and very low-density lipoprotein (VLDL), which functions to remove excess cholesterol. Apo E mediates lipid metabolism and cholesterol homeostasis by binding to several hepatic lipoprotein receptors, such as low density lipoprotein receptor (LDLR) and the LDLR-related protein (1). Apo E deficiency is linked to hyperlipoproteinemia type III; a genetic disorder characterized by elevated plasma cholesterol and triglyceride levels and accelerated coronary artery disease (2). Three major isoforms of Apo E (E2, E3, E4) has been identified, with E3 being the most common in human. E4 presence has been associated to increase probability of developing late-onset form of Alzheimer disease (3). Applications: Suitable for use in ELISA. |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | Human plasma, VLDL |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | A2299-73 |
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| Order / More Info | Apolipoprotein E, Human (Apo E) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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