| 产品详情 |
| Edit |   |
|---|
| Product Name | MALT1 Inhibitor II, Mepazine Hydrochloride |
|---|
| Description | Purity ~97% (HPLC). A cell-permeable phenothiazine that that inhibits MALT1, but not caspase-3 or -8, proteolytic activity (IC50 = 0.83 and 0.42uM, respectively, against full-length or paracaspase domain-catalyzed Ac-LRSR-AMC hydrolysis) in a reversible and noncompetitive manner. Shown to suppress ABC-DLBCL constitutive cellular MALT1 activity (by >75% at 10uM; IC50 <5uM in U2932, OCI-Ly10, OCI-Ly3, HBL1, and TMD8 cultures) and RelB cleavage, resulting in ABC-DLBCL-selective cytotoxicity (≥27% cell death in 4 days at 10uM) over GCB-DLBCL (≤26% cell death in 4 days at 20uM) both in cultures in vitro and in mice (400ug/kg daily i.p.) in vivo. Solubility: DMSO or H2O NMR: Conforms Carbon: As Reported Hydrogen: As Reported Nitrogen: As Reported Sulfur: As Reported LC-MS: As Reported Water by CHN (mol): As Reported |
|---|
| Size | 25mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | MALT1 Inhibitor II, Mepazine Hydrochloride (MALT-1 Inhibitor II, Mucosa-Associated Lymphoid tissue Lymphoma Translocation 1 Inhibitor II, Pacatal, 10-((1-Methylpiperidin-3-yl)methyl)-10H-phenothiazine, Hydrochloride, 10-((1-Methyl-3-piperidyl)methyl)phenothiazine, Hydrochloride, 10-((1-Methyl-3-piperidinyl)methyl)-10H-phenothiazine, Hydrochloride) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217531 |
|---|
| Price | |
|---|
| Order / More Info | MALT1 Inhibitor II, Mepazine Hydrochloride from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|