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Fumarase, Recombinant, Human, aa44-510, (Fumarate hydratase, FH, HLRCC, LRCC, MCL, MCUL1) from UNITED STATES BIOLOGICAL |
| 产品详情 |
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| Product Name | Fumarase, Recombinant, Human, aa44-510, (Fumarate hydratase, FH, HLRCC, LRCC, MCL, MCUL1) |
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| Description | Purity ~95% (SDS-PAGE). Fumarase (Fumarate hytdratase) is an enzyme that catalyzes the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid (TCA), or Krebs cycle. This enzyme exists in both a cytosolic form and an N-terminal extended mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase deficiency can lead to progressive encephalopathy, cerebral atrophy and developmental delay and this enzyme also is thought to act as a tumor suppressor. Source: Recombinant protein corresponding to aa44-510 from human Fumarase, expressed in E. coli. Molecular Weight: ~50.2kD (467aa) Specific Activity: >25unit/mg, and is defined as the amount of enzyme that cleaves 1umole of L-Malate to Fumarate/minute at pH 7.5 at 37°C. Activity Assay: 1. Prepare a 180ul reaction mix into a suitable container: The concentrations are 90mM potassium phosphate, 90 mM L-Malic acid. 2. Equilib |
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| Size | 100ug, 500ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_000134 |
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| Catalog # | 351233 |
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| Order / More Info | Fumarase, Recombinant, Human, aa44-510, (Fumarate hydratase, FH, HLRCC, LRCC, MCL, MCUL1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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