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| Product Name | Recombinant Human papillomavirus type 16 Protein E6 |
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| Description | 1-158aa; Full Length. MW: 23.3kD. Purity >90% as determined by SDS-PAGE. Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting th to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell prolifer |
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| Size | 0.01 mg (E-Coli), 0.01 mg (Yeast), 0.05 mg (E-Coli), 0.05 mg (Yeast), 0.1 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [transforming protein; Protein E6; transforming protein] |
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| Gene, Accession, CAS # | E6, Gene ID: 1489078, Accession: NP_041325.1 |
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| Catalog # | MBS1200699 |
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| Order / More Info | Recombinant Human papillomavirus type 16 Protein E6 from MYBIOSOURCE INC. |
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| Product Specific References | Human papillomavirus type 16 DNA sequence.Seedorf K., Krammer G., Durst M., Suhai S., Rowekamp W.G.Virology 145:181-185(1985) Cloning and sequencing of non-European human papillomavirus (HPV)variant complete genomes from cervicovaginal cells by an overlapping PCR method.Terai M., Fu L., Ma Z., Burk R.D. Expression of the human papillomavirus type 16 genome in SK-v cells, a line derived from a vulvar intraepithelial neoplasia.Schneider-Maunoury S., Pehau-Arnaudet G., Breitburd F., Orth G.J. Gen. |
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