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| Product Name | Recombinant Human papillomavirus type 18 Protein E6 |
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| Description | 1-158. MW: 34.9kD. Purity >90% as determined by SDS-PAGE. Transcriptional transactivator. Binds double-stranded DNA. Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human p53/TP53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity. Interaction with human FBLN1 protein also ses to be linked to cell transformation. |
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| Size | 0.2 mg, 0.5 mg, 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [E6 protein; Protein E6; E6 protein] |
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| Gene, Accession, CAS # | E6, Gene ID: 1489088, Accession: NP_040310.1 |
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| Catalog # | MBS1226909 |
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| Order / More Info | Recombinant Human papillomavirus type 18 Protein E6 from MYBIOSOURCE INC. |
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| Product Specific References | Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products.Cole S.T., Danos O.J. Mol. Biol. 193:599-608(1987) The expression of human papillomavirus type 18 E6 protein in bacteria and the production of anti-E6 antibodies.Matlashewski G., Banks L., Wu-Liao J., Spence P., Pim D., Crawford L.J. Gen. Virol. 67:1909-1916(1986) Nucleotide sequences of cDNAs for human papillomavirus type 18 |
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