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| Product Name | Recombinant Human papillomavirus type 18 Protein E7 (E7) |
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| Description | 1-105. Full length. MW: 16.1kD. Purity >90% as determined by SDS-PAGE. E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled |
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| Size | 0.01 mg (Yeast), 0.05 mg (Yeast), 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.1 mg (Yeast) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Protein E7; Protein E7] |
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| Gene, Accession, CAS # | E7, Accession: P06788.2 |
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| Catalog # | MBS1000515 |
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| Order / More Info | Recombinant Human papillomavirus type 18 Protein E7 (E7) from MYBIOSOURCE INC. |
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| Product Specific References | Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products.Cole S.T., Danos O.J. Mol. Biol. 193:599-608(1987) Nucleotide sequences of cDNAs for human papillomavirus type 18 transcripts in HeLa cells.Inagaki Y., Tsunokawa Y., Takebe N., Nawa H., Nakanishi S., Terada M., Sugimura T.J. Virol. 62:1640-1646(1988) Different human cervical carcinoma cell lines show similar transcription pat |
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