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| Product Name | BRAF, Recombinant, Human, GST-Tag |
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| Description | Purified (~35%). B-Raf, also know as c-Rmil, is a Serine/Threonine protein kinase member of the Raf family which includes Raf-1 and A-Raf. B-Raf is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Composed of three conserved region (CR1, CR2, CR3) B-Raf is expressed primarily in the brain and in the nervous system. It has been observed that MAPK is activated by B-Raf in response to nerve growth factor. More than 60% of malignant melanomas were found to contain a specific mutation, B-Raf (V599E) the product of which possesses constitutive kinase activity. Mutations in B-Raf have also been identified in lung cancer and non-Hodgkin lymphoma. Source: Recombinant corresponding to aa417-766 from human BRAF, fused to GST-tag at N-terminal, expressed in Sf9 cells via a baculovirus expression system. Molecular Weight: ~66kD Applications: Suitable for use in the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | BRAF, Recombinant, Human, GST-Tag (Serine/Threonine-protein Kinase B-raf, Proto-oncogene B-Raf, p94, v-Raf Murine Sarcoma Viral Oncogene Homolog B1, BRAF1, RAFB1) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 137257 |
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| Order / More Info | BRAF, Recombinant, Human, GST-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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