产品名称 DC SIGN-like Antibody from DENDRITICS SAS
产品货号 DDX0200
产品价格 现货询价,电话:010-67529703
产品规格 100µg/50µg
产品品牌 DENDRITICS SAS
产品概述
产品详情
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Antigenic SpecificityDC SIGN-like
Clone118A8.05
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1
Formatpurified
Size100µg/50µg
Concentrationn/a
ApplicationsFACS surface, antigen uptake, IHC, WB
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DescriptionWe have generated an antibody recognizing an antigen which has a tissular distribution and a size (western blot) identical to DC-SIGN. This antibody does not recognize DC-SIGN 1 expressed in HeLa cells. DC-SIGN (``DC Specific, ICAM-3 Grabbing, Nonintegrin'') / CD209 is a type II membrane protein with an external mannose-binding C-type lectin domain, DC-SIGN is expressed by immature and mature dendritic cells (DC). In the skin, DC-SIGN+ DC are exclusively located in the dermis. DC-SIGN binds to ICAM-3 on resting T cells, establishing DC-T cell contact and adaptive immunity. DC-SIGN is a high affinity receptor for HIV gp120, allowing HIV capture and transmission to CD4+ T cells. In addition to HIV, DC-SIGN is a receptor for a number of other viral and cellular pathogens including Mycobacterium Tuberculosis, and is a major player in microbial evasion of the immune system. (Geijtenbeek, T et al, Cell; 2000; 100: 587-597; van Kooyk Y et al, Nat. Rev. Immunol.; 2003; 3: 697-709) (Schwartz Olivier Institut Pasteur-Paris)
Immunogenn/a
Other Namesn/a
Gene, Accession #n/a
Catalog #DDX0200
Price
Order / More InfoDC SIGN-like Antibody from DENDRITICS SAS
Product Specific Referencesn/a
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