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| Product Name | SMN, Recombinant, Human, aa1472-1613, GST-tag |
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| Description | Purity ~90% (SDS-PAGE). Tudor domains are small protein structural motifs of ~50aa related to the ``Royal family'' of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell development, transposon silencing, DNA damage response, histone modification and chromatin remodeling. The tudor domains recognize symmetric methylated arginine or methylated lysine residues. The Survival of Motor Neurons (SMN) protein participates in RNA splicing. The Tudor domain of SMN recognizes and binds methylated Sm proteins, which bind small nuclear RNA. SMN is encoded in humans by two separate genes, SMN1 and SMN2, which differ by one base in exon 7. In motor neuron cells, approximately 90% of the SMN2 transcripts are spliced to exclude exon 7. The SMN2 transcripts without exon 7 are less stable than SMN1 transcripts. Consequently, defects in |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SMN, Recombinant, Human, aa1472-1613, GST-tag (Gemin-1, Component of Gems 1, Survival Motor Neuron Protein) |
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| Gene, Accession, CAS # | SMN1, SMN2, Gene ID: 6606, 6607 |
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| Catalog # | 220273 |
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| Order / More Info | SMN, Recombinant, Human, aa1472-1613, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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