| 产品详情 |
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| Product Name | ICMT Inhibitor |
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| Description | Purity ~95% (HPLC). A cell-permeable indole acetamide that acts as a substrate-competitive and AdoMet-noncompetitive Icmt (isoprenylcysteine carboxyl methyltransferase) inhibitor (Ki=0.02uM; IC50=0.29uM; Substrate=S-farnesyl-L-cysteine), exhibiting no activity against FTase, gernaylgeranyltransferase type I, CaaX protease Rce1, AdoMet-dependent DNA methyltransferase, SssI DNA methyltransferase, or PCMT1 protein methyltransferase. Cysmethynil (25uM) induces G1 cell cycle-arrest and autophagy-mediated, but not apoptotic, cell death in prostate cancer PC3 cells with concomitant PI 3-K/Akt and mTOR signaling blockage, consistent with inhibition of Icmt-mediated activation of Ras and Rheb GTPases. Murine PC3 xenograft studies reveal limited in vivo efficacy. Formula: C25H32N20 Molecular Weight: 376.5 Solubility: DMSO (100mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ICMT Inhibitor (Cysmethynil, 2-(5-(3-Methylphenyl)-1-octyl-1H-indol-3-yl)acetamide, 2-(1-Octyl-5-m-tolyl-1H-indol-3-yl) acetamide, Isoprenylcysteine Carboxyl Methyltransferase Inhibitor) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217447 |
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| Order / More Info | ICMT Inhibitor from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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