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| Antigenic Specificity | Caspase-8, Human |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, rat |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | 100 µg |
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| Concentration | 100 µg/ml |
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| Applications | immunoassay, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The caspase-8 antibody recognizes caspase-8, member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. The caspase-8 polyclonal antibody recognizes endogenous caspase-8. |
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| Immunogen | Synthesized peptide derived from human Caspase-8 around the non-phosphorylation site of S347 |
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| Other Names | CASP-8, Apoptotic protease Mch-5, Apoptotic cysteine protease, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, ICE-like apoptotic protease 5, MACH. |
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| Gene, Accession # | CASP8, MCH5 |
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| Catalog # | HP9061 |
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| Order / More Info | Caspase-8, Human Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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