| 产品详情 |
| Edit |   |
|---|
| Product Name | CRAMP, Mouse, Peptide |
|---|
| Description | Cathelicidins are a familiy of antimicrobial proteins predominantly found in the peroxidase-negative granules of neutrophils. the cathelicidins are synthesized as preproteins. Within the neutrophils, they are stored in granules as inactive proforms after removal of the signal peptide. The biologic active domains of the cathelicidins reside in the C-terminus. The C-terminal antimicrobial peptides are activated when cleaved from the proforms of the cathelicidins by serine proteases from azurophilic granules. Cramp (Cathelin-Related Anti-Microbial Peptide) is the mouse analogue of human LL-37 peptide, which is the antibacterial C-terminus of hCAP-18 (human cathelicidin). CRAMP forms an amphipathic α-helix similar to other antimicrobial peptides. Cramp is a potent antibiotic against Gram-negative bacteria by inhibiting growth of a variety of bacterial strains and by permeabilizing the inner membrane of E.coli directly. Abundant expression of Cramp is found in myeloid precursors and neutrophils. Cramp represents the first antibiotic peptide found in cells of myeloid lineage in the mouse. Inflammatory cells in the mouse can thus use a non-oxidative mechanism for microbial killing. The proteins sequence of CRAMP is ISRLAGLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPE as compared to LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES for human LL-37. |
|---|
| Size | 50 µg |
|---|
| Concentration | Lyophilized product in PBS, containing 50 µg mouse CRAMP. |
|---|
| Applications | functional studies, WB |
|---|
| Other Names | Mouse LL-37, Cathelin-Related Antimicrobial Peptide |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | HC1106 |
|---|
| Price | |
|---|
| Order / More Info | CRAMP, Mouse, Peptide from HYCULT BIOTECH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|