| 产品详情 |
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| Product Name | A-922500 |
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| Description | Purity >95%. Diacylglycerol acyltransferases (DGATs) catalyze the final step in triglyceride synthesis. DGAT-1 deficient mice demonstrate a phenotype that is protective against the development of diet-induced obesity (DIO) or insulin resistance, implicating the actions of this enzyme in the development of such metabolic disorders. A-922500 is a potent orally active inhibitor of DGAT-1 activity, inhibiting both human and mouse forms of the enzymes with IC50 values of 7 and 24 nM, respectively. When administered at 3 mg/kg to DIO mice, A-922500 conferred significant weight loss within seven days without affecting food intake and significantly reduced plasma and liver triglycerides with chronic dosing. A-922500 does not inhibit DGAT-2, ACAT-1, or ACAT-2. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2R-[[4'-[[(phenylamino)carbonyl]amino][1R,1'-biphenyl]-4-yl-carbonyl]-cyclopentanecarboxylic acid, (1R,2R)-2-(4'-(3-phenylureido)biphenylcarbonyl)-cyclopentanecarboxylic acid |
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| Gene, Accession, CAS # | CAS: 959122-11-3 |
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| Catalog # | LS-H6364 |
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| Price | |
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| Order / More Info | A-922500 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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