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| Product Name | Oxidized PAPC |
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| Description | Product Description: Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC) is a prototypic biologically active oxidized phospholipid first isolated from LDL minimally modified by oxidation (MM-LDL). OxPAPC is an active principle of MM-LDL that mimics several pro- and anti-inflammatory effects induced by oxidized lipoproteins. Oxidation of PAPC generates a mixture of oxidized phospholipids containing either fragmented or full-length oxygenated sn-2 residues. The best-cha |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | Application Use: 1. For use of total amount in once: Add buffer or medium used in the experiment and resuspend lipids by vigorous vortexing for at least 30 seconds. Warm the vial up to 30 degree C and vortex again for 1 minute. Avoid preparing concentrated stocks since OxPAPC is poorly soluble in water. Sonicate if necessary to ensure better resuspension of OxPAPC, although that is usually not necessary at concentrations below 150 ug/ml. The concentration range in which OxPAPC can be used depends on the cell type, but usually is below 100 ug/ml. High concentrations of OxPAPC can be toxic. For every new cell and assay type it is recommended to determine time- and concentration dependence. |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | MBS584639 |
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| Order / More Info | Oxidized PAPC from MYBIOSOURCE INC. |
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| Product Specific References | 1. Bochkov, V et al; Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca /NFAT. Blood 2002, 99: 199 2. Birukov, K et al; Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins. Microvasc Res 2004, 67: 18 3. Zheng, M et al; Inhibition of LPS- and CpG DNA-induced TNF-alpha response by oxidized phospholipids. Am J Physiol Lung Cell Mol Physiol 2004, 286: |
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