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| Product Name | S1RA |
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| Description | Purity >98%. The sigma-1 (s1 ) receptor is an intracellular, non-opioid receptor that is abundantly expressed in the central nervous system as well as peripherally. S1RA is a potent, selective antagonist of s1 receptors (Ki = 17 nM) that weakly binds s2 receptors (Ki = 9,300 nM). It is active in vivo, dose-dependently inhibiting neuropathic pain in several animal models, including formalin-induced nociception and capsaicin-induced mechanical hypersensitivity. S1RA enhances peripheral µ-opioid analgesia without affecting opioid-induced constipation. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]-morpholine, E-52862 |
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| Gene, Accession, CAS # | CAS: 878141-96-9 |
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| Catalog # | LS-H9802 |
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| Order / More Info | S1RA from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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