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| Product Name | Tim-3, Recombinant, Human, aa22-200 |
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| Description | Purity ~98% (SDS-PAGE). The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Th1 and Tc1 cells, and generates an inhibitory signal resulting in apoptosis of Th1 and Tc1 cells. TIM-3 is also expressed on some dendritic cells and can mediate phagocytosis of apoptotic cells and cross-presentation of antigen. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses. Tim-3 pathway blockade by administration of Tim |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Tim-3, Recombinant, Human, aa22-200 (TIM3, TIMD3, Hepatitis A Virus Cellular Receptor 2, HAVcr-2, T Cell Immunoglobulin and Mucin Domain-containing Protein 3) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 207425 |
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| Order / More Info | Tim-3, Recombinant, Human, aa22-200 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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