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| Product Name | TIM-2, Recombinant, Mouse, 6-His-Tag |
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| Description | Purity ~95% (SDS-PAGE). T cell immunoglobulin and mucin domain-2 (TIM-2) is an ~50kD member of the TIM family of immune regulatory proteins. TIMs are type I transmembrane proteins with one Ig-like V domain and a Ser/Thr-rich mucin domain in their extracellular regions. Mature mouse TIM-2 consists of a 210aa extracellular domain (ECD), a 21aa transmembrane segment, and a 53aa cytoplasmic domain. Rat TIM-2, by contrast, possesses the same structural architecture as mouse but contains an additional 46aa within the mucin domain. Over comparable regions of the ECD, mouse and rat TIM-2 share 74% aa sequence identity. The isolated ECD forms dimers and tetramers in solution, and these structures suggest the possibility of TIM-2/TIM-2 cis interactions. TIM-2 is expressed on Th2 cells, B cells, oligodendrocytes, hepatocytes, hepatic stellate cells, and epithelial cells lining the bile duct and renal tubules. It is upregulated on Th2 cells during cellular activation and functions as a negative re |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TIM-2, Recombinant, Mouse, 6-His-Tag (T-cell Immunoglobulin and Mucin Domain-containing Protein 2, TIMD-2, T-cell Membrane Protein 2, Timd2, Tim2) |
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| Gene, Accession, CAS # | Accession: NP_599010 |
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| Catalog # | T5469-90 |
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| Order / More Info | TIM-2, Recombinant, Mouse, 6-His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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