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| Product Name | Heat Shock Protein 47, Recombinant, Human |
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| Description | Purity ≥ 90% purified under denaturing conditions from the inclusion body fraction. Hsp47 is a novel 47kD stress glycoprotein. The expression of Hsp47 is highly tissue as well as cell-specific and restricted to mostly phenotypically altered collagen-producing cells (1). Prior to secretion, procollagen molecules are correctly folded to triple helices in the ER where Hsp47 specifically associates with procollagen during its folding and/or modification processes and is thought to function as a collagen-specific molecular chaperone (2). Although the structural requirements for structural recognition and regulation of the binding have not yet been elucidated, it has been proposed that Hsp47 dissociates from procollagen during the process of proly 4-hydroxylation in the ER (3). The expression of Hsp47 is always noted during the process of fibrosis especially around the fibrotic lesions in both humans and experimental animals. These observations suggest that upregulation of Hsp47 may play a |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | Heat Shock Protein 47, Recombinant, Human (HSP47, Colligin, gp46, AsTP3, CBP1, CBP2, Collagen-binding protein 1, Collagen-binding protein 2 precursor, Colligin 1, Colligin 2, gp46, HSP47, arthritis-related antigen RA-A47, SERPINH2) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | H1830-66 |
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| Order / More Info | Heat Shock Protein 47, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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