产品名称 CD46, Human Antibody from HYCULT BIOTECH
产品货号 HM2103F
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 HYCULT BIOTECH
产品概述
产品详情
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Antigenic SpecificityCD46, Human
CloneM177
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1
Formatfluorescein (FITC) conjugate
Size100 µg
Concentration100 µg/ml
Applicationsfrozen sections, FC, functional studies, immunoassay, IP, WB
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DescriptionThe monoclonal antibody M177 recognizes CD46, also designated membrane cofactor protein (MCP). CD46 is a 45-70 kDa protein with genetic and tissue-specific heterogeneity.- It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to inhibit complement activation on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus. Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)). The monoclonal antibody M177 reacts with the SCR2 domain.
ImmunogenPurified MCP
Other NamesMembrane cofactor protein, TLX, trophoblast leucocyte common antigen.
Gene, Accession #CD46
Catalog #HM2103F
Price
Order / More InfoCD46, Human Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
产品资料