| 产品详情 |
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| Product Name | PDGFRb/RAF Kinase Inhibitor |
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| Description | Purity ~95% (HPLC). An orally bioavailable amino-triazole compound that is shown to bind to the inactive conformations of both PDGFRb and Raf kinases (allosteric, Type II inh), and acts as a potent inhibitor of Flt3, Kit, PDGFRa and PDGFRb (=52, 170, 300 and 520nM, respectively) with selectivity over B-Raf, p38a, FGFR2 and VEGFR2 (>10uM) in a multi-kinase panel. Completely blocks the phosphorylations of MEK-1/2 S217/S221, ERK-1/2 T202/Y204 in FGF-stimulated HUVECs, PDGFRb in PDGF-BB-stimulated VSMCs, ERK-1/2 T202/Y204 in 1205Lu-B Raf V600E cells, and C-Raf S338 at 10uM. Reduces FGF-induced angiogenesis in mouse Matrigel model (50mg/kg, i.p., bid) and selectively induces apoptosis in the endothelium; further, suppresses orthotopic renal cell carcinoma growth in mice (100mg/kg, p.o., qd). Formula: C20H16F3N7OS Molecular Weight: 459.6 Solubility: DMSO |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PDGFRb/RAF Kinase Inhibitor (6-(4-(5-(3-(Trifluoromethyl)phenylamino)-4 H-1,2,4-triazol-3-yl)phenoxy)-2-(methylthio)pyrimidin-4-amine , PDGFR Tyrosine Kinase Inhibitor XXII) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217637 |
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| Order / More Info | PDGFRb/RAF Kinase Inhibitor from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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