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| Antigenic Specificity | TNF-alpha, Human |
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| Clone | 5N |
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| Host Species | Mouse |
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| Reactive Species | human, bovine, canine, monkey |
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| Isotype | IgG2a |
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| Format | unconjugated |
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| Size | 0.5 mg |
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| Concentration | 500 µg/ml |
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| Applications | functional studies, immunoassay |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The monoclonal antibody 5N reacts with Tumor Necrosis Factor alpha (TNF-alpha). Tumor necrosis factor-alpha (TNF-alpha), a homotrimeric 17 KD protein, is a potent mediator of inflammatory and metabolic functions. TNF-alpha was originally detected as a highly cytotoxic cytokine for tumor cells, it causes tumor necrosis in vivo and shows cytolytic activity against tumor cells in vitro. Further TNF-alpha has been implied as central mediator in shock induced by gram negative micro-organisms. The cytokine TNF-alpha is found to be a central mediator in many inflammatory and immunological processes: it can be induced by various products of micro-organisms and by various cytokines but it also induces on its turn the production of many cytokines. Signal transduction occurs via two types of TNF-receptors, the TNF-receptors I and II. The receptors differ strongly in their intra-cellular signaling pathways. The TNF-alpha trimer interacts with either of the two types of TNF-R leading to receptor cross-linking. The monoclonal antibody 5N cross-reacts and cross-neutralizes all monkey species TNF-alpha, except pig-tail macaque. With affinity about two orders lower it recognizes bovine and canine TNF-alpha. |
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| Immunogen | n/a |
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| Other Names | TNF, TNF-SF2, DIF, Cachectin |
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| Gene, Accession # | n/a |
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| Catalog # | HM2218-FS |
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| Price | |
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| Order / More Info | TNF-alpha, Human Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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