| 产品详情 |
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| Antigenic Specificity | Gemin 2 |
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| Clone | 2E17 |
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| Host Species | Mouse |
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| Reactive Species | mouse, human, Xenopus laevis |
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| Isotype | IgG1 |
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| Format | Protein A purified |
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| Size | 50ul |
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| Concentration | 1mg/ml |
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| Applications | Flow Cyt, ICC/IF, ELISA, WB, IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Mouse Anti-Gemin 2 [2E17]. |
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| Immunogen | His-Gemin 2 fusion protein (amino acids 12 - 280, starting at 2nd methionine) |
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| Other Names | Component of gems 2, GEMI2_HUMAN, Gemin-2, gemin2, SIP 1; SIP-1, SIP1, SIP1 delta, SMN interacting protein 1, SMNinteracting protein 1 delta, SMN-interacting protein 1, Survival interacting protein 1; Survival of motor neuron protein interacting protein 1, Survival of motor neuronprotein-interacting protein 1 |
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| Gene, Accession # | n/a |
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| Catalog # | IQ260 |
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| Price | |
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| Order / More Info | Gemin 2 Antibody from IMMUQUEST LTD. |
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| Product Specific References | The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. Liu Q ( Cell,Sep 1997)PUBMED Sanchez G et al. A novel function for the survival motoneuron protein as a translational regulator. Hum Mol Genet : (2012)PUBMED Wu CY et al. Proteomic assessment of a cell model of spinal muscular atrophy. BMC Neurosci 12:25 (2011).WB ; MousePUBMED Takizawa Y et al. GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination. Nucleic Acids Res. 2010 Aug;38(15):5059-74. doi: 10.1093/nar/gkq271. Epub 2010 Apr 19.WB; HumanPMID: 20403813 Burnett BG et al. Regulation of SMN protein stability. Mol Cell Biol 29:1107-15 (2009).WB ; HumanPUBMED Walker MP et al. SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain. Hum Mol Genet 17:3399-410 (2008).ICC/IF ; MousePUBMED Morency E et al. A novel cell response triggered by interphase centromere structural instability. J Cell Biol 177:757-68 (2007).ICC/IF ; HumanPUBMED RenvoisA B et al. Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells. J Cell Sci 119:680-92 (2006)PUBMED |
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