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| Product Name | Pdia2, Recombinant, Mouse, aa1-302, His-Tag (Pituitary Homeobox 3) |
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| Description | Purity ~85% (SDS-PAGE). Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the tporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens e |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Homeobox protein PITX3, Paired-like homeodomain transcription factor 3 |
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| Gene, Accession, CAS # | SwissProt: O35160 |
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| Catalog # | 374646 |
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| Order / More Info | Pdia2, Recombinant, Mouse, aa1-302, His-Tag (Pituitary Homeobox 3) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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