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| Product Name | HOP, p60, Recombinant, Human (HSP70 HSP90 Organizing Protein) |
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| Description | Purity ≥90% (SDS-PAGE). Hsp70-Hsp90 Organizing Protein (HOP, p60) is an ~60kD protein that is a critical intermediate component for the efficient maturation of steroid receptor complexes (1-3), serving to recruit Hsp90 to Hsp70-containing complexes. Unactivated steroid hormone receptors are found in hetero-oligomeric complexes that are thought to stabilize a partially folded receptor polypeptide prior to hormone-dependent activation (4-6). Hsp70 and Hsp90 are both known to associate with steroid hormone receptors. Numerous studies (8-13) have shown that Hsp70 functions in an ATP-dependent manner through transient interactions to mediate folding or unfolding of polypeptide chains. Hsp90 is thought to perhaps also function in some capacity related to folding or protein-protein interactions (14). HOP contains three tetratricopeptide repeat (TPR) domains, TPR1, TPR2a and TPR2b. Hsp70 binding has been localized to TPR1, and Hsp90 binding has been localized to TPR2a. Importantly, the highly |
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| Size | 50ug, 200ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P31948 |
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| Catalog # | H7021-10 |
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| Price | |
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| Order / More Info | HOP, p60, Recombinant, Human (HSP70 HSP90 Organizing Protein) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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