| 产品详情 |
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| Product Name | trans-Ned-19 |
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| Description | Purity >98%. Nicotinic acid adenine dinucleotide phosphate (NAADP) is a dinucleotide second messenger that triggers the release of calcium from lysosomes and related cellular compartments. trans -Ned-19 is a structural analog of NAADP that blocks NAADP-dependent calcium release (IC50 = 6 nM) as well as NAADP binding to sea urchin egg homogenate (IC50 = 0.4 nM). The trans form of Ned-19 is significantly more potent than the cis isomer in both assays. Ned-19 does not affect either IP3 -mediated calcium release or cyclic ADP-ribose-mediated calcium release. It directly binds NAADP receptors on lysosomes in mouse pancreatic beta cells and competitively antagonizes activation by NAADP. It inhibits glucose-induced calcium oscillations in pancreatic islets and insulin-induced calcium increases in 3T3-L1 adipocytes. Ned-19 also blocks calcium signaling induced by endothelin-1 or norepinephrine in renal afferent arterioles. Ned-19 dose-dependently reduces infection of host cells by Ebola virus. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (1R,3S)-1-[3-[[4-(2-fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid |
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| Gene, Accession, CAS # | CAS: 1354235-96-3 |
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| Catalog # | LS-H10279 |
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| Order / More Info | trans-Ned-19 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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