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| Product Name | Axl, Fc Chimera, Recombinant, Mouse, CF |
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| Description | Purity ~95% (SDS-PAGE). Axl, also known as Ufo and Ark, is a widely expressed 140kD glycoprotein in the TAM receptor tyrosine kinase family. TAM family receptors (Dtk/Tyro3, Axl, and Mer) are involved in regulation of the inflammatory response, cell survival and migration, and tumorigenesis. Mature mouse Axl consists of a 427aa extracellular domain (ECD) that contains two Ig-like domains and two fibronectin type III domains, a 21aa transmembrane segment, and a 422aa cytoplasmic domain that includes the tyrosine kinase domain. Within the ECD, mouse Axl shares 81% and 95% aa sequence identity with human and rat Axl, respectively. Axl binds the vitamin K dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl cytoplasmic domain. Activation of Axl induces a broad range of activities including platelet aggregation and thrombus formation, macrophage and dendritic cell phagocytosis of apoptotic cells, NK cell development from hematopoietic progenitor cells, and in vivo a |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Axl, Fc Chimera, Recombinant, Mouse, CF (Tyrosine-protein Kinase Receptor UFO, Adhesion-related Kinase, Ark, Ufo) |
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| Gene, Accession, CAS # | SwissProt: Q00993 |
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| Catalog # | A4775-11 |
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| Order / More Info | Axl, Fc Chimera, Recombinant, Mouse, CF from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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